Proteomics of breast cancer for individualized medicine
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- Research Group
Min Jia, Olena Zakharchenko, Kah Wai Lin, Christina Greenwood, Nazariy Souchelnytskyi for more information.
- Description
We focus on human breast cancer. The goal is to understand molecular mechanisms governing breast cancer, develop novel anti-cancer drugs, markers for diagnostics and early detection, and develop tools for individualized treatment of patients.
To achieve these goals, we use proteomics, molecular and cellular biology, systems biology and clinical studies.
Carcinogenic transformation is a complex process of acquiring by normal cells abilities to uncontrolled and unlimited proliferation, escaping death-inducing signals, and developing capacities to spread in the body. We apply proteomics to unveil molecular mechanisms of carcinogenic transformation of human breast epithelial cells. We exploit these mechanisms to develop novel anti-cancer treatments.
We develop and apply systems biology tools, in order to unveil systemic properties of carcinogenic transformation. We want to understand how multiple signals integrate in cells, and how we can use this knowledge for improvement of cancer treatment.
Combinatorial use of different drugs in treatment of cancer is an example of multiple signals. Which drugs and in which combination to use for a specific patient? This question is to be answered by Cancer Systems Biology, including CellProDe tool under development in our group.
Transforming growth factor-beta signaling in breast cancer is the area of our particular interest.
We search for markers for early detection and for improved diagnostics and management of breast cancer.
We are open for collaborations, as to battle cancer, clinicians and scientists from different fields have to unite their efforts.
We also are looking for cooperation with public organizations to raise awareness of cancer problems.
Do not hesitate to contact us, if you have suggestions.
Serhiy Souchelnytskyi
For publication and other information, including our OACE technology platform, see http://ki.se/ki/jsp/polopoly.jsp?d=28768&l=en
